Hydration, Peptides, Retinol: The Triple Threat for Wrinkle Repair

Wrinkles are a part of aging, but modern skincare offers effective tools in the form of hydrating ingredients, like hyaluronic acid, skincare peptides, and retinol. These active ingredients work to plump the skin, restore collagen levels, and promote a smooth skin texture. And using them together as part of your daily routine offers synergistic benefits.

If you’re concerned about wrinkly skin and wonder how can I get smooth skin, today’s article is for you. We will discuss:

• Why skin hydration matters for smooth skin
• Skincare peptides and why you want them in your routine
• What is retinol? And retinol benefits for skin health and anti-aging
• How to use retinol serum and other active ingredients together for the best results
• Building a personalized skincare routine to address wrinkles from multiple angles

Why Hydration Matters for Wrinkle Repair

Along with aging, the associated loss of collagen, and sun damage, dehydration affects skin health and contributes to fine lines and wrinkles. Water helps give the skin a plump structure, and when it doesn’t have enough, you’ll notice more sagging, wrinkles, and crepiness. Hydrating the skin will produce noticeable results and help to minimize the appearance of wrinkles.

Hyaluronic acid is one of the most hydrating ingredients you’ll find in skincare products. It’s a molecule naturally found in the fluid between cells throughout the body, particularly in the skin. It declines with age but can be restored with topical application, allowing it to penetrate the skin and pull water (and other skincare ingredients) with it for deep hydration and nourishment.

The Role of Peptides in Smoothing Skin 

Peptides are small proteins that act as signaling molecules in the skin. They signal skin cells to do specific things, such as:

• Increase collagen production
• Block collagen breakdown
• Strengthen the skin barrier
• Increase the healing response

Because of these signaling actions, skincare peptides aid in the softening of fine lines and promote smoothing effects. If you want your skin-smoothing cream to work, look for peptides in the formulation. Some of the best ones are: Lipopeptide Complex, Renovage, Argireline Amplified, Eyeseryl Solution B, Crystalide, and NassifMD Upfinity Peptide Complex. 

How Retinol Rebuilds and Restores Collagen

When it comes to wrinkle reduction and how to get smooth skin, retinol is one of the best ingredients to use. In fact, retinol is an FDA-approved anti-wrinkle agent. 

What does retinol do? Retinol is a retinoid, an active form of vitamin A that’s involved in genetic expression, tissue regeneration, and skin health. Applying retinol topically helps to improve the skin’s structure (more collagen!), increase hydration, and support the skin barrier. These actions combined reduce the appearance of fine lines and wrinkles, promoting a bright, even, and smooth complexion. 

Combining Hydration, Peptides, and Retinol Safely

Addressing wrinkles requires a comprehensive approach, including hyaluronic acid, peptides, and retinol. These ingredients don’t need to be in a single product, but you can use them each in the context of your skincare routine. While we’ll offer specific wrinkle-reducing product suggestions from NassifMD® facial plastic surgeon skincare next, let’s discuss some guidelines and safety considerations. 

• Hylauronic acid is incredibly safe, and you’ll find it throughout the NassifMD® Skincare line. You may use it daily, either in a single product or as part of multiple products in your skincare routine. 
• Use skincare peptides once or twice daily as part of your skincare routine. You can also combine multiple peptide formulas to address specific concerns. 
• The timing and frequency of retinol use may depend on your skin type and other factors. If you are new to retinol, start by using it twice per week. Retinol will promote skin turnover, so it’s possible to experience some skin peeling as you use it. As your skin tolerates, you can increase use to daily. We recommend using retinol at night and then sunscreen the next day (and every day) as retinol can increase photosensitivity. It’s also important to moisturize when using retinol. 

Building a Skincare Routine for Wrinkle Repair 

After cleansing your skin, there are many NassifMD® Skincare options to support wrinkle reduction. While you don’t necessarily need every product listed here, you can pick and choose according to your needs, ensuring that you have hyaluronic acid, peptides, and retinol covered. 

Additionally, please note that we will highlight some of the wrinkle-reducing active ingredients in each product, but these products have additional active ingredients and benefits, so they are worth exploring in more detail to discover what’s best for your skin. View all the products that work to address fine lines and wrinkles here. 

Skin Toner

• NassifMD® 3HA Hydrating Facial Mist addresses fine lines and wrinkles with three types of hyaluronic acid. Apply after cleansing and before the rest of your routine, or use anytime your skin needs a refreshing plump. 

Detox and Retexturizing Pads

• NassifMD® Even Correct & Renew Retexturizing Pads feature Hy-Retin, retinol bound to hyaluronic acid, for supercharged anti-wrinkle benefits. 
• NassifMD® Detox Facial Pads offer gentle exfoliation along with bakuchiol, a retinol-like molecule, and a gentle alternative to retinol, offering similar benefits. 

Facial Serums

• NassifMD® Pro Peptide Collagen Serum features Lipopeptide Complex to aid in building collagen and elastin that fills in wrinkles and plumps the skin. It also contains Hydraglucan, a blend of hyaluronic acid, betaine, and beta-glucan. 
• NassifMD® Hydro-Screen Serum offers both hyaluronic acid and retinol in this popular retinol serum designed to hydrate, nourish, and firm the skin. 
• NassifMD® Night Therapy Serum is the best retinol option for nighttime use. It also contains retinol and hyaluronic acid to firm and plump the skin while you sleep. 
• NassifMD® Hydro-Gel Serum is an oil-free, water-based serum featuring Hy-Retin. It’s an excellent option for oily or acne-prone skin. 
• NassifMD® Niacinamide Biopeptide Serum contains 300 natural peptides from cranberry, along with niacinamide for powerful wrinkle support. 
• Use a gua sha tool or facial roller along with serums to increase their absorption and offer additional skin-smoothing benefits. You’ll find everything you need with NassifMD® Ultimate Sculpt and Hydrate Kit. 

Eye Treatments

• NassifMD® Quickfix Instant Wrinkle Smoother contains hyaluronic acid along with additional ingredients to blur wrinkles and tighten the skin around the eyes temporarily. 
• NassifMD® Age Defying Eye Renewal Serum contains Argireline Amplified and Eyeseryl Solution B, which are both powerful peptide complexes aimed at improving skin health and reducing crow’s feet and wrinkles around the eyes. 
• NassifMD® Under Eye Anti Aging Smoother targets the delicate skin around the eyes with Eyeseryl Solution B peptides to reduce puffiness and improve skin elasticity. 

Neck and Decollete Care

• NassifMD® Deco-Lift Neck & Decollete Firming & Lifting Complex features Renovage peptide complex to restore the skin’s moisture balance, boost skin elasticity, and reduce the appearance of fine lines and wrinkles. 
• NassifMD® Age Defying Neck & Decollete Serum also targets wrinkly neck skin with peptides, this time with NassifMD® Upfinity Peptide Complex to improve collagen levels, provide natural lift, and reduce lines and wrinkles. 

Moisturizers and Body Care

• NassifMD® Soft Focus Hydrating Day Cream is a daytime moisturizer featuring Crystalide peptide and hyaluronic acid to smooth, plump, and hydrate the skin. 
• NassifMD® Crepe Inhibitor Triple Action Body Butter supports firmness and tightening all over the body with Renovage peptide complex. 
• NassifMD® Hydro-Screen Soufflé is another body and face product designed to hydrate and moisturize deeply. It features hyaluronic acid with additional active ingredients. 
• Addressing wrinkles is about more than finding the best retinol cream; it’s about incorporating hydrating skincare with retinol and peptides in a way that works within your skincare routine. With so many expertly formulated options, you can’t go wrong when you choose NassifMD® facial plastic surgeon skincare. 

References:

1. Juncan, A. M., Moisă, D. G., Santini, A., Morgovan, C., Rus, L. L., Vonica-Țincu, A. L., & Loghin, F. (2021). Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules (Basel, Switzerland), 26(15), 4429.
2. Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International journal of cosmetic science, 31(5), 327–345.
3. Zasada, M., & Budzisz, E. (2019). Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy dermatologii i alergologii, 36(4), 392–397.